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NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
4-DIMETHYLAMINOANTIPYRINE
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 001143
*CAS NUMBER: 58-15-1
*BASE CHEMICAL NAME: DIMETHYLAMINOANTIPYRINE,4-
*PRIMARY NAME: 4-DIMETHYLAMINOANTIPYRINE
*CHEMICAL FORMULA: C13H17N3O
*STRUCTURAL FORMULA: Not printable
*WLN: T5NNVJ A1 BR& DN1&1 E1
*SYNONYMS:
AMIDOPYRINE
DIMETHYLAMINOANTIPYRINE
AMINOPYRINE
4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
4-DIMETHYLAMINOPHENAZONE
4-(DIMETHYLAMINO)-1,2-DIHYDRO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE
1-PHENYL-2,3-DIMETHYL-4-DIMETHYLAMINOPYRAZOLONE-5
P-DIMETHYLAMINOANTIPYRINE
AMIDAZOFEN
AMIDAZOPHEN
AMIDAZOPHENE
AMIDOFEBRIN
AMIDOFEN
AMIDOPHEN
AMIDOPHENAZONE
AMIDOPYRAZOLINE
AMIDOPYRIN
AMINOPHENAZONE
ANAFEBRINA
BRUFANEUXOL
DAP
DEREUMA
DIMAPYRIN
DIMETHYLAMINOANALGESINE
DIMETHYLAMINOAZOPHENE
4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE
DIMETHYLAMINOPHENAZONE
DIMETHYLAMINOPHENYLDIMETHYLPYRAZOLIN
DIMETHYLAMINOPHENYLDIMETHYLPYRAZOLONE
4-DIMETHYLAMINO-1-PHENYL-2,3-DIMETHYLPYRAZOLONE
1,5-DIMETHYL-4-DIMETHYLAMINO-2-PHENYL-3-PYRAZOLONE
2,3-DIMETHYL-4-DIMETHYLAMINO-1-PHENYL-5-PYRAZOLONE
DIPIRIN
DIPYRIN
DIPYRINE
FEBRININA
FEBRON
ITAMIDONE
3-KETO-1,5-DIMETHYL-4-DIMETHYLAMINO-2-PHENYL-2,3-DIHYDROPYRAZOLE
MAMALLET-A
NETSUSARIN
NOVAMIDON
1-PHENYL-2,3-DIMETHYL-4-DIMETHYLAMINOPYRAZOL-5-ONE
PIRAMIDON
PIRIDOL
PIROMIDINA
POLINALIN
PYRADONE
PYRAMIDON
PYRAMIDONE
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: Small colorless crystals or white crystalline
powder
REPOSITORY: White powder
*MOLECULAR WEIGHT: 231.30
*SPECIFIC GRAVITY: Not available
*DENSITY: Not available
*MP (DEG C): 107-109 C [031,042]
*BP (DEG C): Not available
*SOLUBILITIES:
WATER : >=100 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: 1 g/1.5 mL [031]
Benzene: 1 g/12 mL [031]
Chloroform: 1 g/1 mL [031]
Ether: 1 g/13 mL [031]
*VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
*FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
*UEL: Not available LEL: Not available
*REACTIVITY:
This chemical is readily attacked by mild oxidizing agents in the
presence of water [031]. It is incompatible with acacia, apomorphine,
aspirin, chloral hydrate, iodine and tannic acid [295].
*STABILITY:
This chemical is sensitive to exposure to light [031,295]. UV spectro-
photometric stability screening indicates that solutions of this chemical in
water are stable for at least 24 hours (RAD).
*OTHER PHYSICAL DATA:
Melting point also reported as 134-135 C [016,047]
Solubility in water is increased by the addition of sodium benzoate [031]
Aqueous solution is slightly alkaline to litmus [031]
pH (5% water solution): 7.5-9 [295]
Odorless [295]
Slightly bitter taste [295]
-TOXICITY
========
*NIOSH REGISTRY NUMBER: CD2625000
*TOXICITY:
typ. dose mode specie amount units other
LD50 ims mus 306 mg/kg
LD50 ims rat 340 mg/kg
LD50 ipr ham 380 mg/kg
LD50 ipr mam 300 mg/kg
LD50 ipr mus 169 mg/kg
LD50 ipr rat 190 mg/kg
LDLo ivn cat 100 mg/kg
LD50 ivn dog 121 mg/kg
LD50 ivn gpg 130 mg/kg
LD50 ivn mus 78 mg/kg
LD50 ivn rat 98 mg/kg
LD50 ivn rbt 80 mg/kg
LDLo orl cat 100 mg/kg
LD50 orl dog 220 mg/kg
LD50 orl gpg 910 mg/kg
LD50 orl mus 350 mg/kg
LD50 orl rat 600 mg/kg
LD50 orl rbt 600 mg/kg
LDLo par frg 900 mg/kg
LDLo scu gpg 250 mg/kg
LD50 scu mus 248 mg/kg
LD50 scu rat 295 mg/kg
LDLo scu rbt 250 mg/kg
LDLo unr man 220 mg/kg
LDLo unr mus 225 mg/kg
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: Human poison by unspecified route. Experimental poison by ingestion,
subcutaneous, intramuscular, intravenous, implant and possibly other
routes. Moderately toxic by parenteral route. An experimental tera-
togen. Experimental reproductive effects. Mutation data. Mixed with
NaNO2 (1:1), it is an experimental carcinogen.
*CARCINOGENICITY: Not available
*MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
cyt-ham:fbr 3 mmol/L | dni-mus:oth 100 mg/L
dnr-esc 1250 ug/well | msc-ham-orl 100 mg/kg
mma-sat 31 umol/plate | otr-ham-orl 100 mg/kg
otr-rat-orl 2520 mg/kg/6W |
*TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-mus 60 mg/kg (7-12D preg)
TDLo: orl-mus 900 mg/kg (7-12D preg)
TDLo: orl-rat 60 mg/kg (9-14D preg)
TDLo: orl-rat 900 mg/kg (9-14D preg)
TDLo: scu-mus 630 mg/kg (9-11D preg)
TDLo: scu-mus 600 mg/kg (7-9D preg)
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
*OTHER TOXICITY DATA:
Status: EPA Genetox Program 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1989
Meets criteria for proposed OSHA Medical Records Rule
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Not restricted
*UN/ID NUMBER:
*HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
*LABELS REQUIRED:
*PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
*SPECIAL PROVISIONS:
*USES:
This chemical is used in human and veterinary medicine as an antipyretic,
analgesic and anti-inflammatory agent. It is also sometimes used in drug meta-
bolism. It is also used as a tranquilizer.
*COMMENTS:
Clinical use of this compound has been sharply curtailed due to its
potentially fatal bone-marrow toxicity [406].
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits toxic fumes of nitrogen
oxides [043].
*MINIMUM PROTECTIVE CLOTHING: Not available
*RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont 25-545 0.07 mm 240 min
Nitrile Edmont 37-155 0.40 mm 240 min
Viton North F-091 0.24 mm 240 min
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
*OTHER: Not available
*STORAGE PRECAUTIONS:
You should protect this material from exposure to light, and store
it in a refrigerator.
*SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound include allergic reactions, strong
spasmolytic effect on smooth muscle of peripheral blood vessels, irritability,
palsy, copious sweating, dilated pupils, sharp drop then rise in body tempera-
ture, dysuria, dyspnea, anxiety, tenesmus, urinary frequency, intermittent
fever, fatty infiltration of the liver, heart muscle degeneration and death
due to circulatory failure following cardiovascular collapse [151]. Agranulo-
cytosis often occurs [031,295,301,406]. Ingestion may cause central nervous
system stimulation, vomiting, convulsions, cyanosis, tinnitus, leukopenia,
kidney damage and coma [151,301]. Ingestion may also lead to nausea, mental
disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigas-
tric pain, difficulty in hearing, thready pulse and liver damage [301]. Other
symptoms reported via ingestion include hemolytic anemia, porphyria and severe
gastrointestinal bleeding [295]. Bone marrow depression also occurs [043].
Rare eye effects include acute transient myopia [099].
Chronic symptoms include anorexia, edema, oliguria, urticaria, hyper-
sensitivity, aplastic anemia, sore throat, fever, pharygeal membrane, jaundice,
enlargement of the liver and spleen, exfoliative dermatitis, gastric or duo-
denal erosion with perforation or bleeding, adrenal necrosis, thrombocytopenic
purpura and acute leukemia [301].
-SOURCES
=======
*SOURCES:
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of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. CD2625000.
September 19, 1989.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-86, #1334.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 71, #480.
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[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
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[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
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Edition. 5 Vols. U.S. Environmental Protection Agency.
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 78.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
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[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
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[406] Goodman, L.S., A. Gilman, F. Murad and T.W. Rall, Eds. The
Pharmacological Basis of Therapeutics. 7th Ed. Macmillan
Publishing Co. New York. 1985. pp. 690-692.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
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[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
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Not listed.
Last update: Mar 27, 2009; 1:25 p.m. LAH