Calcium Channel Blocker

by: Joe Hing Kwok Chu

Calcium ions are needed for muscle contraction of smooth muscle and cardiac muscle. Excess calcium ions in the cells causes cell death and loss of function. Calcium channel blockers prevent the calcium ions from entering the cells of smooth and cardiac muscle, thus causing the blood vessel walls to relax and to enable blood to flow more freely to the heart and relieving anginal pain. They are mainly used in treatment of certain heart conditions and stroke but they are also used in migraine therapy and potentially for Alzheimer disease. Certain calcium channel blockers, such as nifefipine (trade names: Adalat; Adapine; Nifecard; Nyefax; Adalat; Procardia; Adalat; Cardilate; Coracten; Nifensar; Hypolar; Adipine Cardifen (SA) ) slow the electrical impulses that run through heart muscle, thus regulating arrhythmias.

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