Pharmaceutical name:

英文药名：

Cortex Magnoliae Officinalis

Biological name:

拉丁植物学名：

Magnolia officinalis Rehd. et Wils. ssp. biloba（Rehd. et Wils.）Law

Magnolia  obovata, Thunb. (produced in Japan)

Magnolia fargesii

Magnolia biloba (Rehd． Et Wils.) Cheng (凹葉厚朴)

Pron. in Japanese:

日語發音：

koboku

Pron. in Korean:

韓語發音：

mubak

Pron. in Cantonese:

粤語發音：

hau5 pok3

Common Name:

英文名：

magnolia bark

Other Names:

别名：

shan he hua (山荷花)﹐ he hua po (荷厚樸) , he hua mu lan  (荷花木蘭)

Distribution:

産地：

Sichuan, Hunan, Hubei, Zhejian, Guangxi, Jiangxi. Sichuan, Guizhou, Yunnan, Shaanxi, Anhui, Gansu provinces of China.

Magnolia biloba (Rehd． Et Wils.) Cheng is distributed in Zhejiang, Jiangxi, Anhui, Guangxi provinces. Mainly produced in Sichuan, Hubei, Zhejiang, Guizhou, and Hunan provinces of China.

厚朴分布浙江，廣西，江西，湖南，湖北，四川，貴州，雲南，陝西，安徽，甘肅等地。

凹葉厚朴分布浙江，江西，安徽，廣西等地。主產四川，湖北，浙江，貴州，湖南。

Properties (characteristics)

性味：

bitter, acrid warm and aromatic

味苦，辛﹐温，香。

Channels (meridians) entered:

歸經：

large intestine, lung, spleen, stomach

大腸，肺，脾，胃。

Actions & Indications:

主治：

transform phlegm and rids of dampness and stagnation in spleen and stomach indigestion, flatulence, loss of appetite, vomiting, diarrhea and constipation.

具有燥濕消痰，下氣除滿之功能。
用於濕滯傷中，脘痞吐瀉，食積氣滯，腹脹便秘，痰飲喘咳。

Medical Function:

藥理：

1. the decoction in test tubes show that it had strong inhibition of Staphylococcus aureus

2. relaxing skeletal muscle effect

3. improves digestion, inhibits pain and sedative effect

4. anti-coagulation of platelets

5. anti-cancer

6. potential as a novel therapeutic agent for the treatment of atherosclerosis and re-stenosis.[1]

7. induces apoptosis in acute myelogenous leukemia (AML) cells.

8.  honokiol induces apoptosis in B-cell chronic lymphocytic leukemia (B-CLL)[2]

1. 本品煎劑在試管中，對金黃色葡萄球菌有很強的抑制作用。

2. 鬆弛骨骼肌作用﹐

3. 健胃﹐鎮痛﹐鎮靜，

4. 抗血小板凝集，

5. 抗癌，

6. 可能對抗動脈粥樣硬化有發展前途[1]

7. 和厚朴酚可使急性颗粒白血病细胞凋亡，

8. 和厚朴酚可使慢性淋巴细胞白血病细胞凋亡。[2]

Chemical ingredients:

化學成份：

Chemical ingredients:

1. Magnolol 厚朴酚, tetrahydromagnolol, isomagnolol, honokiol 和厚朴酚, Randainal, syringaresinol, syringaresinol 4-O-Beta-D-glucopyranoside, 6'-O-methyl-honokiol, magnaldehyde, B, C; magnolignan A, B, C, D, E.

2. Magnatriol B, magnaldehyde #, #,; Randaiol.

3. Magnolignan F, G, H, I.

4. Piperitylmagnolol, pipertylhonokiol, dipiperitylmagnolol, bornylmagnolol.

5. Eudesmol, alpha-pinene, Beta-pinene, p-cymene; 1, 4-cineol; alpha-limonene, carene-3, linalool, beta-bisabolene, terpinen-4-ol, alpha-terpineol, bornyl acetate, linalyl acetate, caryophyllene, alphe-humulene, alphe-copaene, aromadendrene, alloaromadendrene, alpha-cedrene, elemeol, Globulol, alpha-santalol, butylidenecyclohexane, guaiol, beta-guaiene, Cardinol, guaiazulene.

6. Magnocurarine

7. Sinapic aldehyde, 1-(4-hydroxy-3-methoxyphenyl) -2 -(4_ (W-hydroxypropyl) - 2-methoxyphenoxy) propane-1, 3-diol.

Dosage:

用量：

3- 12 g;

hou pu hua (flower):3-6 g

Samples of formulae:

處方舉例：

hou pu san wu tang 厚樸三物湯

da cheng tang 大成湯 (外科正宗)

Modern Research:

现代研究：

One of the active chemicals. honokiol, can cause B-cells of lymphocytic leukemia into apoptosis[1]. Honokiol does not ge destroyed by the digestive system readily. It can be effective in decoction.

厚朴酚能使到淋巴白血病之B细胞凋亡]1]。厚朴酚不易被消化系统破壞，所以厚朴用於湯剤會有效。

Cautions:

禁忌：

Use caution during pregnancy.

It antagonizes ze xie and han shui shi.

Large dosages and/or long term usage can be toxic to kidneys.

懷孕期間，小心應用。反澤 蘭或寒水石。大劑量或長期服用可能對腎臟有毒。