Pharmaceutical name:

英文藥名﹕

Zoological name of source materials:

拉丁動物學名﹕

Elaphe taeniura Copa (黑眉錦蛇)

Elaphe carinata Günther (錦蛇)

Zaocys dhumnades Cantor (烏梢蛇)

Natrix piscator Schneider (漁游蛇)

Pron. in Japanese:

日語發音﹕

Pron. in Korean:

韓語發音﹕

Pron. in Cantonese::

粵音﹕

Other Names:

別名﹕

long zi yi 龍子衣，she fu 蛇符，long zi dan yi 龍子單衣，gong pi 弓皮，long pi 龍皮，long dan yi 龍 單衣，she jun 蛇筋，she fu 蛇附，she pi 蛇皮，long zi pi 龍子皮，she tui pi 蛇蛻皮，she ke 蛇 殼，she tui 蛇退，long yi 龍衣，qing long yi 青龍衣，chang chong pi 長虫皮，bai ling yi 白龍衣

Common Name:

英文名﹕

Distribution:

產地﹕

主產浙江，廣西，四川，江蘇，福建，安徽 ，陝西，雲南等地。

Properties

(characteristics)﹕

性味﹕

甘，鹹，平。

Channels (meridians) entered:

歸經﹕

肝，脾。

藥理﹕

1. The anti-inflammatory effect: Indomethacin (indomethacin, IDM), Phenylbutazone, PB were used as control drugs. Male rats (200-300g body weight) and Dd strain male mice (20g) were used. The feed and water were fed ad libitum. Experimental results show that: 1.1. Acute toxicity test, no significant toxicity. Method preparation: using snake slough boiled water extract, freeze-dried to produce yellow-brown powder. The yield was 5.4%.
1.2: The inhibition of leukocyte mobility effect: Using extract of 20mg/kg intravenously, the  inhibition rate was approximately 51.1% (P <0.01). The inhibition of leukocyte mobility of using daily oral administration of 200mg/kg for 5 days: the inhibition rate was 33.7% (P <0.02 ).

.2. Paw edema inhibition effect: inhibition of edema caused by carrageenan, using oral administering of the herb extract was ineffective. But, using 50mg/kg subcutaneous injection and 20mg/kg intravenous injection showed that using IDM was equally effective in anti-edema effect. After intravenous 20mg/kg2 hours to inflammatory agents, it resulted in an anti-edema effect. In mustard paste (Mustarol) induced edema, the IDM inhibited edema after 7 days of application. Using this herb (snake slough) extract took six days, but  it is the same as using phenylbutazone; there was no persistent anti-edema effect.
3. For vascular hyperpermeability inhibition: dose of 100mg/kg taken orally can inhibit the dextran-induced skin edema. The herb  inhibition rate was 60% (P <0.02). For the  control group using drug IDM10mg/kg, the inhibition rate was 37.5% (P <0.01). The inhibition rate of the spread of pigment extract only was  15% (P <0.05),  Using IDM, the inhibition rate was 72.6% (P <0.01), This indicates a different mechanism of action of the two drugs.(she tui and IDM).
4. The thermal hemolysis of red blood cells inhibitory effect of the extract of 4mg and 12mg was 20.5% (P <0.01) and 48% (P <0.01). That was equivalent to IDM1mg, phenylbutazone or 5mg hemolysis inhibition.

藥理﹕　

1．抗炎症作用：採用煮沸的蛇蛻水提取物，凍干後得黃褐色粉末，得率為5.4%。用消炎痛（Indomethacin，IDM）、保秦松（Phenylbutazone，PB）作為對照藥物。動物採用雄性大鼠（200-300g體重）和 Dd系雄性小鼠（20g）。飼料、水自由攝取。實驗結果表明：

1.1.急性毒性試驗無明顯的毒性。

1.2.對白血球游走的抑制作用表明：提取液20mg/kg靜脈注射，抑制率約 51.1%（P<0.01），每天口服200mg/kg，5天抑制率為33.7%（P<0.02）。
　　2．對足跖浮腫的抑制作用：對角叉菜膠所致浮腫的抑制作用，口服無效。50mg/kg皮下注射和20mg/kg靜脈注射呈現與 IDM同等顯著的抗浮腫作用。給發炎劑後，靜脈注射20mg/kg2小時後出現明顯的抗浮腫作用。對芥末糊（Mustarol）所致浮腫的抑制作用，IDM在7天後有抑制浮腫的作用。蛇蛻提取液從第6天開始有效，但與保泰鬆一樣都無持續抗浮腫作用。
　　3．對血管通透性亢進的抑制作用：劑量為100mg/kg口服對葡聚糖所致皮膚浮腫抑制率 60%（P<0.02）。口服對照藥物 IDM10mg/kg抑制率為37.5%（P<0.01），但對色素擴散的抑制率，提取液僅為15%（P<0.05），IDM則為72.6%（P<0.01），這表明兩種藥物的作用機理不同。
　　4．對紅血球熱溶血的抑制作用：提取液4mg和12mg的抑制作用分別為20.5%（P<0.01）和48%（P<0.01）；相當於IDM1mg，保泰鬆 5mg 對溶血的抑制作用。
 

Actions & Indications:

主治﹕

用於小兒驚風，抽搐痙攣，翳障，喉痺，疔腫 ，湯傷，皮膚瘙痒。

Chemical ingredients:

化學成份﹕

Daily Dosage:

每日用量﹕

2～3 g；研末吞服 0.3～0.6 g

Samples of formulae:

處方舉例﹕

Modern Research:

現代研究﹕

Toxicity & Cautions:

毒素與禁忌﹕

孕婦忌用。